Osamu Kikuchi Selected Research

Esophageal Squamous Cell Carcinoma

1/2022	Multicenter phase II study of trifluridine/tipiracil for esophageal squamous carcinoma refractory/intolerant to 5-fluorouracil, platinum compounds, and taxanes: the ECTAS study.
1/2020	Protective effects of Alda-1, an ALDH2 activator, on alcohol-derived DNA damage in the esophagus of human ALDH2*2 (Glu504Lys) knock-in mice.
1/2020	Synthetic Lethality with Trifluridine/Tipiracil and Checkpoint Kinase 1 Inhibitor for Esophageal Squamous Cell Carcinoma.
8/2019	Combination treatment with highly bioavailable curcumin and NQO1 inhibitor exhibits potent antitumor effects on esophageal squamous cell carcinoma.
1/2017	Distinct effects of EGFR inhibitors on epithelial- and mesenchymal-like esophageal squamous cell carcinoma cells.
3/2016	Novel EGFR-targeted strategy with hybrid peptide against oesophageal squamous cell carcinoma.
9/2015	Protective role of ALDH2 against acetaldehyde-derived DNA damage in oesophageal squamous epithelium.
1/2015	Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression.
1/2014	Impairment of aldehyde dehydrogenase 2 increases accumulation of acetaldehyde-derived DNA damage in the esophagus after ethanol ingestion.
1/2014	Preclinical validation of talaporfin sodium-mediated photodynamic therapy for esophageal squamous cell carcinoma.

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Osamu Kikuchi Research Topics

Disease

10	Esophageal Squamous Cell Carcinoma 01/2022 - 01/2014
10	Neoplasms (Cancer) 01/2022 - 01/2014
4	Obesity 01/2015 - 01/2013
2	Type 2 Diabetes Mellitus (MODY) 04/2022 - 11/2021
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2022 - 01/2019
2	Esophageal Neoplasms (Esophageal Cancer) 01/2022 - 01/2019
2	Colorectal Neoplasms (Colorectal Cancer) 01/2022 - 09/2015
2	Carcinogenesis 01/2020 - 12/2015
2	Adenocarcinoma 12/2019 - 03/2008
2	Metabolic Syndrome (Dysmetabolic Syndrome X) 11/2017 - 02/2012
2	Insulin Resistance 01/2015 - 10/2014
1	Squamous Cell Carcinoma of Head and Neck 01/2019
1	Esophageal Stenosis (Esophageal Stricture) 10/2016
1	Hyperphagia (Overeating) 01/2015
1	Growth Disorders 01/2015
1	Thinness 10/2014
1	AIDS-Related Complex (ARC) 04/2014
1	Weight Gain 04/2014
1	Dyspepsia (Indigestion) 01/2013
1	Body Weight (Weight, Body) 01/2013
1	Hypoglycemia (Reactive Hypoglycemia) 01/2013
1	Hyperglycemia 01/2013
1	Glucose Intolerance 03/2012
1	Liver Abscess 01/2012
1	Aneurysm (Aneurysms) 04/2009
1	Stomach Neoplasms (Stomach Cancer) 03/2008
1	Pancreatic Neoplasms (Pancreatic Cancer) 03/2008
1	Pain (Aches) 03/2008
1	Neoplasm Metastasis (Metastasis) 03/2008
1	Gallbladder Neoplasms (Gallbladder Cancer) 03/2008

Drug/Important Bio-Agent (IBA)

5	Insulin (Novolin)FDA Link 04/2022 - 02/2012
4	AcetaldehydeIBA 01/2020 - 01/2014
3	Fluorouracil (Carac)FDA LinkGeneric 01/2022 - 01/2015
3	Proteins (Proteins, Gene)FDA Link 01/2020 - 04/2014
3	CarcinogensIBA 01/2020 - 01/2014
3	Pharmaceutical PreparationsIBA 11/2017 - 01/2013
2	Glucagon (Glukagon)FDA Link 04/2022 - 11/2021
2	trifluridine tipiracil drug combinationIBA 01/2022 - 01/2020
2	ErbB Receptors (EGF Receptor)IBA 01/2017 - 03/2016
2	Peptides (Polypeptides)IBA 03/2016 - 04/2014
2	Aldehyde DehydrogenaseIBA 12/2015 - 01/2014
2	Ethanol (Ethyl Alcohol)IBA 09/2015 - 01/2014
2	LeptinIBA 01/2015 - 04/2014
2	Glucose (Dextrose)FDA LinkGeneric 01/2015 - 03/2012
2	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 10/2014 - 04/2014
2	Sirtuin 1IBA 10/2014 - 04/2014
1	PlatinumIBA 01/2022
1	AfatinibIBA 01/2022
1	Tyrosine Kinase InhibitorsIBA 01/2022
1	Biological ProductsIBA 01/2022
1	Platinum Compounds (Compounds, Platinum)IBA 01/2022
1	Taxoids (Taxanes)IBA 01/2022
1	Phosphotransferases (Kinase)IBA 01/2020
1	Checkpoint Kinase 1IBA 01/2020
1	Dronabinol (THC)FDA LinkGeneric 08/2019
1	CurcuminIBA 08/2019
1	Messenger RNA (mRNA)IBA 01/2019
1	IncretinsIBA 11/2017
1	Cetuximab (Erbitux)FDA Link 01/2017
1	involucrinIBA 01/2017
1	Peptide FragmentsIBA 03/2016
1	peptide AIBA 03/2016
1	EnzymesIBA 12/2015
1	MicroRNAs (MicroRNA)IBA 09/2015
1	Biomarkers (Surrogate Marker)IBA 09/2015
1	Blood Glucose (Blood Sugar)IBA 01/2015
1	Insulin SecretagoguesIBA 01/2015
1	Dihydrouracil Dehydrogenase (NADP) (Dihydropyrimidine Dehydrogenase)IBA 01/2015
1	Insulin-Like Growth Factor Binding Protein 3IBA 01/2015
1	Forkhead Box Protein O1IBA 10/2014
1	NAD (NADH)IBA 04/2014
1	Non-Receptor Type 2 Protein Tyrosine PhosphataseIBA 04/2014
1	CytokinesIBA 04/2014
1	Sucrose (Saccharose)IBA 04/2014
1	Non-Receptor Type 1 Protein Tyrosine PhosphataseIBA 04/2014
1	1-phenyl-3,3-dimethyltriazene (PDT)IBA 01/2014
1	Talaporfin (talaporfin sodium)IBA 01/2014
1	Photosensitizing Agents (Photosensitizers)IBA 01/2014
1	Nonesterified Fatty Acids (NEFA)IBA 01/2013
1	Acarbose FDA LinkGeneric 01/2013
1	Glycoside Hydrolase InhibitorsIBA 01/2013
1	miglitol (Glyset)FDA Link 01/2013
1	CarbohydratesIBA 01/2013
1	PotassiumIBA 03/2008
1	Gemcitabine FDA Link 03/2008
1	tegafur-gimeracil-oteracilIBA 03/2008
1	Tumor Biomarkers (Tumor Markers)IBA 03/2008

Therapy/Procedure

3	Drug Therapy (Chemotherapy) 01/2022 - 03/2008
3	Therapeutics 12/2019 - 01/2019
2	Radiotherapy 01/2020 - 12/2015
1	Precision Medicine 01/2019
1	Neoadjuvant Therapy 01/2019
1	Catheters 10/2016
1	Photochemotherapy (Photodynamic Therapy) 01/2014
1	Critical Care (Surgical Intensive Care) 01/2012
1	Surgical Instruments (Clip) 04/2009
1	Combination Drug Therapy (Combination Chemotherapy) 03/2008
1	Gastrectomy 03/2008